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"Can't Seem to Make You Mine" is a song by American rock group The Seeds, written by vocalist Sky Saxon and produced by Marcus Tybalt. It was released as a single in 1965 and re-issued in 1967, when it peaked at number 41 on the U.S. Billboard Hot 100 chart.
The song appears on the 1998 box set Nuggets: Original Artyfacts from the First Psychedelic Era, 1965–1968, and has been covered by such artists as the Ramones, Alex Chilton, Johnny Thunders, Yo La Tengo and Garbage.